TargetMol

IDF-11774

Product Code:
 
TAR-T5537
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5537-1mg1mg£115.00
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Quantity:
TAR-T5537-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T5537-5mg5mg£161.00
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TAR-T5537-10mg10mg£229.00
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TAR-T5537-25mg25mg£334.00
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Quantity:
TAR-T5537-50mg50mg£463.00
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Quantity:
TAR-T5537-100mg100mg£643.00
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This product comes from: United States.
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Further Information

Bioactivity:
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
CAS:
1429054-28-3
Formula:
C23H32N2O2
Molecular Weight:
368.521
Pathway:
Chromatin/Epigenetic; Metabolism; Angiogenesis
Purity:
0.98
SMILES:
CN1CCN(CC1)C(=O)COc1ccc(cc1)C12CC3CC(CC(C3)C1)C2
Target:
HIF/HIF Prolyl-Hydroxylase; HIF

References

Chang L L, Lu P H, Yang W, et al. AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1? and metabolic reprogramming. Translational Oncology. 2022, 20: 101421 Ban H S , Kim B K , Lee H , et al. The novel hypoxia-inducible factor-1? inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth[J]. Cell Death and Disease, 2017, 8(6):e2843.