TargetMol

Alisol B

Product Code:
 
TAR-T5770
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5770-1mg1mg£122.00
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TAR-T5770-5mg5mg£229.00
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TAR-T5770-1mL1 mL * 10 mM (in DMSO)£253.00
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TAR-T5770-10mg10mg£306.00
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TAR-T5770-25mg25mg£470.00
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TAR-T5770-50mg50mg£627.00
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TAR-T5770-100mg100mg£859.00
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Further Information

Bioactivity:
Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis.
CAS:
18649-93-9
Formula:
C30H48O4
Molecular Weight:
472.71
Pathway:
NF-κb
Purity:
0.9977
SMILES:
[H][C@@]1(OC1(C)C)[C@@H](O)C[C@@H](C)C1=C2C[C@H](O)[C@@]3([H])[C@@]4(C)CCC(=O)C(C)(C)[C@]4([H])CC[C@]3(C)[C@@]2(C)CC1
Target:
RANKL/RANK

References

[Alisol B inhibited complement 3a-induced human renal tubular epithelial to mesenchymal transition]. Lee J W , Kobayashi Y , Nakamichi Y , et al. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice[J]. Biochemical Pharmacology, 2010, 80(3):352-361.