TargetMol

XL388

Product Code:
 
TAR-T6030
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6030-1mg1mg£101.00
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TAR-T6030-2mg2mg£113.00
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TAR-T6030-5mg5mg£142.00
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TAR-T6030-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T6030-10mg10mg£185.00
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TAR-T6030-25mg25mg£309.00
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TAR-T6030-50mg50mg£463.00
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TAR-T6030-100mg100mg£646.00
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This product comes from: United States.
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Further Information

Bioactivity:
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
CAS:
1251156-08-7
Formula:
C23H22FN3O4S
Molecular Weight:
455.5
Pathway:
PI3K/Akt/mTOR signaling; Metabolism
Purity:
0.9953
SMILES:
Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O
Target:
P45; PI3K; mTOR

References

Wang Z, Feng J, Yu J, et al. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Journal of Cell Science. 2019, 132(10): jcs227777 Takeuchi CS, et al. J Med Chem, 2013, 56(6), 2218-2234. Nicole Miller, et al. Mol Cancer Ther, 2009, 8(12 Suppl):B146. Chen C, Zhang X, Wang Y, et al. Translational and Post-translational Control of Human Na?ve versus Primed Pluripotency. iScience. 2021: 103645. Wang Z, Feng J, Yu J, et al. FKBP12 mediates necroptosis by initiating RIPK1?RIPK3?MLKL signal transduction in response to TNF receptor 1 ligation[J]. Journal of cell science. 2019 May 20;132(10). pii: jcs227777.