TargetMol

Licofelone

Product Code:
 
TAR-T6568
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6568-1mg1mg£97.00
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TAR-T6568-2mg2mg£105.00
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TAR-T6568-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6568-5mg5mg£112.00
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TAR-T6568-10mg10mg£148.00
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TAR-T6568-25mg25mg£201.00
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TAR-T6568-50mg50mg£266.00
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TAR-T6568-100mg100mg£359.00
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TAR-T6568-200mg200mg£499.00
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  • Further Information
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Further Information

Bioactivity:
Licofelone is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase).
CAS:
156897-06-2
Formula:
C23H22ClNO2
Molecular Weight:
379.88
Pathway:
Immunology/Inflammation; Metabolism; Apoptosis; Neuroscience
Purity:
0.9949
SMILES:
CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
Target:
Apoptosis; Lipoxygenase; COX

References

https://www.ncbi.nlm.nih.gov/pubmed/8021931 Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.