TargetMol

Desmethyl Erlotinib hydrochloride

Product Code:
 
TAR-T6619
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6619-1mg1mg£114.00
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TAR-T6619-2mg2mg£132.00
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TAR-T6619-5mg5mg£164.00
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TAR-T6619-1mL1 mL * 10 mM (in DMSO)£174.00
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TAR-T6619-10mg10mg£230.00
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TAR-T6619-25mg25mg£354.00
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TAR-T6619-50mg50mg£498.00
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TAR-T6619-100mg100mg£679.00
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This product comes from: United States.
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Further Information

Bioactivity:
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
CAS:
183320-51-6
Formula:
C21H22ClN3O4
Molecular Weight:
415.87
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Metabolism
Purity:
0.9903
SMILES:
Cl.COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO
Target:
EGFR; Drug Metabolite

References

Ali S, et al. Mol Cancer Ther, 2008, 7(6), 1708-1719. Moyer JD, et al. Cancer Res. 1997, 57(21), 4838-4848. Meany HJ, et al. Cancer Chemother Pharmacol. 2008, 62(3), 387-392. Li T, et al. Clin Cancer Res, 2007, 13(11), 3413-3422. Buck E, et al. Mol Cancer Ther. 2006, 5(11), 2676-2784.