TargetMol

GGTI298 Trifluoroacetate

Product Code:
 
TAR-T6844
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6844-1mg1mg£134.00
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TAR-T6844-5mg5mg£201.00
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TAR-T6844-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-T6844-10mg10mg£264.00
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TAR-T6844-25mg25mg£397.00
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TAR-T6844-50mg50mg£546.00
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Further Information

Bioactivity:
GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
CAS:
1217457-86-7
Formula:
C29H34F3N3O5S
Molecular Weight:
593.66
Pathway:
MAPK; Apoptosis; GPCR/G Protein; Metabolism
Purity:
0.9815
SMILES:
OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12
Target:
Apoptosis; Transferase; Ras

References

Stark WW Jr, et al. Am J Physiol. 1998, 275(1 Pt 1):L55-63. Zhang Y, Yu G, Chu H, et al. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis. Molecular Cell. 2018, 71(2): 201-215. e7 Sun J, et al. J Biol Chem. 1999, 274(11):6930-4. Lau CP, et al. Connect Tissue Res. 2015, 56(6):493-503. Zhang Yajuan, et al. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis[J]. Molecular cell. 2018 Jul 19;71(2):201-215.e7.