TargetMol

Ganoderic acid A

Product Code:
 
TAR-T6S1141
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S1141-1mg1mg£102.00
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TAR-T6S1141-5mg5mg£149.00
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TAR-T6S1141-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T6S1141-10mg10mg£201.00
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TAR-T6S1141-25mg25mg£282.00
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TAR-T6S1141-50mg50mg£386.00
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TAR-T6S1141-100mg100mg£533.00
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Further Information

Bioactivity:
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human osteosarcoma HOS and MG-63 cells. 3. Ganoderic acid A promotes cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression, significantly suppresses IL-6-induced signal transducer and activator of transcription 3 phosphorylation.
CAS:
81907-62-2
Formula:
C30H44O7
Molecular Weight:
516.675
Pathway:
Apoptosis; NF-κb; Autophagy; Metabolism
Purity:
0.9931
SMILES:
CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O
Target:
Apoptosis; NF-κB; Endogenous Metabolite; Autophagy

References

Shao J , Li Z , Jiao G , et al. [Ganoderic acid A suppresses proliferation and invasion and induces apoptosis in human osteosarcoma cells].[J]. Journal of Southern Medical University, 2015, 35(5):619.