TargetMol

Shogaol

Product Code:
 
TAR-T6S1699
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S1699-1mg1mg£95.00
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TAR-T6S1699-5mg5mg£121.00
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TAR-T6S1699-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T6S1699-10mg10mg£149.00
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TAR-T6S1699-25mg25mg£230.00
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TAR-T6S1699-50mg50mg£320.00
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TAR-T6S1699-100mg100mg£453.00
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Further Information

Bioactivity:
1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.
CAS:
555-66-8
Formula:
C17H24O3
Molecular Weight:
276.37
Pathway:
Metabolism; Autophagy
Purity:
0.9939
SMILES:
CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1
Target:
Lipoxygenase; Autophagy

References

Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021?1781 Han M A , Woo S M , Min K J , et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression[J]. Chem Biol Interact, 2015, 228:69-78. Kamaruddin M S H, Chong G H, Umanan F, et al.Enhancement of 6-gingerol extraction from Bentong ginger using supercritical carbon dioxide.Journal of CO2 Utilization.2023, 72: 102505.