TargetMol

Batefenterol

Product Code:
 
TAR-T7079
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T7079-1mg1mg£127.00
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TAR-T7079-2mg2mg£149.00
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TAR-T7079-5mg5mg£189.00
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TAR-T7079-10mg10mg£254.00
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TAR-T7079-1mL1 mL * 10 mM (in DMSO)£270.00
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TAR-T7079-25mg25mg£414.00
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TAR-T7079-50mg50mg£583.00
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TAR-T7079-100mg100mg£787.00
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Further Information

Bioactivity:
Batefenterol (GSK961081, TD-5959) is a muscarinic receptor antagonist and β2-adrenoceptor agonist. It displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor (Ki:1.4/1.3/3.7 nM).
CAS:
743461-65-6
Formula:
C40H42ClN5O7
Molecular Weight:
740.25
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.984
SMILES:
COc1cc(NC(=O)CCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
Target:
Adrenergic Receptor; AChR

References

Hughes AD, et al. Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and ?? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD). J Med Chem. 2015 Mar 26;58(6):2609-22. Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and ?2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351(1):190-9.