TargetMol

GLPG1837

Product Code:
 
TAR-T7083
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7083-1mg1mg£114.00
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TAR-T7083-2mg2mg£122.00
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TAR-T7083-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T7083-5mg5mg£164.00
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TAR-T7083-10mg10mg£197.00
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TAR-T7083-25mg25mg£274.00
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TAR-T7083-50mg50mg£376.00
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TAR-T7083-100mg100mg£524.00
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TAR-T7083-500mg500mg£1,058.00
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Further Information

Bioactivity:
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
CAS:
1654725-02-6
Formula:
C16H20N4O3S
Molecular Weight:
348.42
Pathway:
Autophagy; Membrane transporter/Ion channel
Purity:
0.9973
SMILES:
CC1(C)Cc2c(sc(NC(=O)c3cc[nH]n3)c2C(N)=O)C(C)(C)O1
Target:
CFTR; Autophagy

References

Yeh HI, et al. A common mechanism for CFTR potentiators. J Gen Physiol. 2017 Dec 4;149(12):1105-1118. Van der Plas SE, et al. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61(4):1425-1435.