TargetMol

CAY10594

Product Code:
 
TAR-T7280
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7280-1mg1mg£132.00
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TAR-T7280-5mg5mg£201.00
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TAR-T7280-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T7280-10mg10mg£294.00
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TAR-T7280-25mg25mg£470.00
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TAR-T7280-50mg50mg£651.00
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TAR-T7280-100mg100mg£863.00
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Further Information

Bioactivity:
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
CAS:
1130067-34-3
Formula:
C26H28N4O2
Molecular Weight:
428.536
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1
Target:
Phospholipase

References

Pupovac A , Stokes L , Sluyter R . CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation[J]. Purinergic Signalling, 2013, 9(4):609-619. Liu Z, Nan Y, Luo Q, et al. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Research. 2022 Lee SK, Bae GH, Kim YS,et al.A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3?/JNK axis[J].Sci Rep. 2019 May 10;9(1):7242. Zhang Y, Li Y, Liu P, et al. Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin[J]. Journal of extracellular vesicles. 2021, 10(5): e12078. Zhang Y, Li Y, Liu P, et al. Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin. Journal of extracellular vesicles. 2021 Mar;10(5):e12078. doi: 10.1002/jev2.12078. Epub 2021 Mar 10.