TargetMol

ARS-853

Product Code:
 
TAR-T7414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7414-1mg1mg£193.00
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TAR-T7414-1mL1 mL * 10 mM (in DMSO)£372.00
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TAR-T7414-5mg5mg£385.00
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TAR-T7414-10mg10mg£539.00
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TAR-T7414-25mg25mg£823.00
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TAR-T7414-50mg50mg£1,091.00
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Quantity:
TAR-T7414-100mg100mg£1,452.00
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TAR-T7414-500mg500mg£2,825.00
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Further Information

Bioactivity:
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
CAS:
1629268-00-3
Formula:
C22H29ClN4O3
Molecular Weight:
432.95
Pathway:
Apoptosis; MAPK; GPCR/G Protein
Purity:
0.9834
SMILES:
CC1(CC1)c1cc(NCC(=O)N2CCN(CC2)C2CN(C2)C(=O)C=C)c(O)cc1Cl
Target:
Apoptosis; Raf; Ras

References

Patricelli M P , Janes M R , Li L S . Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.[J]. Cancer Discovery, 2016, 6(3):316. Lito P , Solomon M , Li L S , et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism[J]. Science, 2016:science.aad6204.