TargetMol

ML228

Product Code:
 
TAR-T7836
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7836-1mg1mg£100.00
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TAR-T7836-5mg5mg£142.00
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TAR-T7836-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T7836-10mg10mg£201.00
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TAR-T7836-25mg25mg£359.00
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TAR-T7836-50mg50mg£522.00
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TAR-T7836-100mg100mg£705.00
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Further Information

Bioactivity:
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF.
CAS:
1357171-62-0
Formula:
C27H21N5
Molecular Weight:
415.49
Pathway:
Chromatin/Epigenetic; Angiogenesis
Purity:
0.9903
SMILES:
N1=NC(C2=CC=CC=C2)=C(N=C1C=3N=CC=CC3)NCC=4C=CC(=CC4)C=5C=CC=CC5
Target:
HIF

References

Theriault JR, et al. Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg Med Chem Lett. 2012 Jan 1;22(1):76-81. Chen H, et al. Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats.Exp Ther Med. 2017 Mar;13(3):861-866. Theriault JR, et al. Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway. Probe Reports from the NIH Molecular Libraries Program.