TargetMol

PBD-150

Product Code:
 
TAR-T7905
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7905-1mg1mg£111.00
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TAR-T7905-2mg2mg£130.00
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TAR-T7905-5mg5mg£168.00
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TAR-T7905-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T7905-10mg10mg£252.00
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TAR-T7905-25mg25mg£389.00
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TAR-T7905-50mg50mg£544.00
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TAR-T7905-100mg100mg£748.00
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This product comes from: United States.
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Further Information

Bioactivity:
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
CAS:
790663-33-1
Formula:
C15H20N4O2S
Molecular Weight:
320.41
Pathway:
Neuroscience
Purity:
1
SMILES:
COc1ccc(NC(=S)NCCCn2ccnc2)cc1OC
Target:
Beta Amyloid

References

Huang, K.-F, Liaw, S.-S, Huang, W.-L,et al. Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding[J]. Journal of Biological Chemistry, 286(14):12439-12449. Dipisa F , Pozzi C , Benvenuti M , et al. The soluble Y115E?Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease[J]. Acta Crystallographica, 2015, 71(8):986-992.