TargetMol

Dimethyl lithospermate B

Product Code:
 
TAR-T8299
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8299-1mg1mg£222.00
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TAR-T8299-5mg5mg£527.00
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TAR-T8299-1mL1 mL * 10 mM (in DMSO)£672.00
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TAR-T8299-10mg10mg£707.00
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TAR-T8299-25mg25mg£1,018.00
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TAR-T8299-50mg50mg£1,380.00
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TAR-T8299-100mg100mg£1,830.00
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Further Information

Bioactivity:
Dimethyl lithospermate B is a selective Na+ channel agonist.
CAS:
875313-64-7
Formula:
C38H34O16
Molecular Weight:
746.674
Pathway:
Membrane transporter/Ion channel
Purity:
0.9962
SMILES:
COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(=O)OC)c12)c1ccc(O)c(O)c1
Target:
Sodium Channel

References

Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73. Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400.