TargetMol

AS2863619

Product Code:
 
TAR-T8378
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8378-1mg1mg£177.00
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Quantity:
TAR-T8378-2mg2mg£222.00
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TAR-T8378-5mg5mg£303.00
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TAR-T8378-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T8378-10mg10mg£436.00
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TAR-T8378-25mg25mg£675.00
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Quantity:
TAR-T8378-50mg50mg£922.00
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Quantity:
TAR-T8378-100mg100mg£1,219.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
CAS:
2241300-51-4
Formula:
C16H14Cl2N8O
Molecular Weight:
405.24
Pathway:
Stem Cells; JAK/STAT signaling; Cell Cycle/Checkpoint
Purity:
1
SMILES:
Cl.Cl.Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
Target:
CDK; STAT

References

Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.