TargetMol

CPYPP

Product Code:
 
TAR-T8527
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8527-1mg1mg£102.00
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TAR-T8527-5mg5mg£135.00
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TAR-T8527-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T8527-10mg10mg£168.00
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TAR-T8527-25mg25mg£269.00
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TAR-T8527-50mg50mg£389.00
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TAR-T8527-100mg100mg£546.00
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Further Information

Bioactivity:
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9
CAS:
310460-39-0
Formula:
C18H13ClN2O2
Molecular Weight:
324.76
Purity:
0.9985
SMILES:
Clc1ccccc1C=CC=C1C(=O)NN(C1=O)c1ccccc1

References

Ferrandez Y , Zhang W , Peurois F , et al. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule[J]. entific Reports, 2017, 7(1):14409. Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.