TargetMol

PF-05186462

Product Code:
 
TAR-T8711
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8711-1mg1mg£177.00
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TAR-T8711-5mg5mg£313.00
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TAR-T8711-1mL1 mL * 10 mM (in DMSO)£383.00
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TAR-T8711-10mg10mg£434.00
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TAR-T8711-25mg25mg£670.00
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Quantity:
TAR-T8711-50mg50mg£914.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
CAS:
1235406-03-7
Formula:
C19H10ClF4N5O3S2
Molecular Weight:
531.88
Pathway:
Membrane transporter/Ion channel
Purity:
0.9937
SMILES:
Fc1cc(Oc2ccc(cc2-c2ccnnc2)C(F)(F)F)c(Cl)cc1S(=O)(=O)Nc1nncs1
Target:
Sodium Channel

References

Hannah M Jones , Richard P Butt , Rob W Webster,et al.Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.Clin Pharmacokinet. 2016 Jul;55(7):875-887.