TargetMol

iGOT1-01

Product Code:
 
TAR-T8765
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8765-1mg1mg£163.00
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TAR-T8765-5mg5mg£303.00
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TAR-T8765-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T8765-10mg10mg£442.00
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TAR-T8765-25mg25mg£671.00
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TAR-T8765-50mg50mg£863.00
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TAR-T8765-100mg100mg£1,179.00
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TAR-T8765-500mg500mg£2,295.00
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This product comes from: United States.
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Further Information

Bioactivity:
iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.
CAS:
882256-55-5
Formula:
C19H20N4O
Molecular Weight:
320.39
Purity:
0.9983
SMILES:
O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=CC=C4

References

Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. Melissa C Holt, et al. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614.