TargetMol

NAE-IN-M22

Product Code:
 
TAR-T8816
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8816-1mg1mg£145.00
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TAR-T8816-5mg5mg£254.00
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TAR-T8816-1mL1 mL * 10 mM (in DMSO)£274.00
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TAR-T8816-10mg10mg£343.00
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TAR-T8816-25mg25mg£533.00
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TAR-T8816-50mg50mg£733.00
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TAR-T8816-100mg100mg£978.00
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TAR-T8816-500mg500mg£1,910.00
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Further Information

Bioactivity:
NAE-IN-M22 is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.
CAS:
864420-54-2
Formula:
C20H24Cl2N2
Molecular Weight:
363.33
Pathway:
Ubiquitination; Apoptosis
Purity:
0.9867
SMILES:
Clc1ccc(CCNC2CCN(Cc3ccccc3)CC2)c(Cl)c1
Target:
Apoptosis; E1/E2/E3 Enzyme

References

Tian T, Xie X, Yi W, et al.FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.Cell Reports.2023, 42(11). Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.