TargetMol

IMT1B

Product Code:
 
TAR-T8842
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8842-1mg1mg£195.00
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TAR-T8842-5mg5mg£334.00
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TAR-T8842-1mL1 mL * 10 mM (in DMSO)£346.00
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TAR-T8842-10mg10mg£523.00
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TAR-T8842-25mg25mg£785.00
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TAR-T8842-50mg50mg£1,058.00
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Quantity:
TAR-T8842-100mg100mg£1,412.00
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Quantity:
TAR-T8842-500mg500mg£2,761.00
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This product comes from: United States.
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Further Information

Bioactivity:
IMT1B is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. It has anti-tumour effects.
CAS:
2304621-06-3
Formula:
C24H21ClFNO6
Molecular Weight:
473.88
Pathway:
Cell Cycle/Checkpoint|Others|DNA Damage/DNA Repair
Purity:
0.9826
SMILES:
C[C@@H](Oc1ccc2c(cc(=O)oc2c1)-c1ccc(F)cc1Cl)C(=O)N1CCC[C@@H](C1)C(O)=O
Target:
Others|DNA/RNA Synthesis

References

Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.