TargetMol

hSMG-1 inhibitor 11j

Product Code:
 
TAR-T8884
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8884-1mg1mg£201.00
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TAR-T8884-2mg2mg£266.00
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TAR-T8884-5mg5mg£402.00
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TAR-T8884-10mg10mg£567.00
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TAR-T8884-25mg25mg£862.00
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TAR-T8884-50mg50mg£1,139.00
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This product comes from: United States.
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Further Information

Bioactivity:
hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.
CAS:
1402452-15-6
Formula:
C27H28ClN7O3S
Molecular Weight:
566.07
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9922
SMILES:
O=C(NC1=CC=C(C=C1)C2=NC=CC(=C2)C3=NC(=NC=C3)NC4=CC=C(Cl)C(=C4)S(=O)(=O)N(CC)CC)NC
Target:
PI3K; mTOR

References

Gopalsamy A, et, al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.