TargetMol

YUM70

Product Code:
 
TAR-T8901
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8901-1mg1mg£125.00
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TAR-T8901-5mg5mg£189.00
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TAR-T8901-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T8901-10mg10mg£254.00
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TAR-T8901-25mg25mg£442.00
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TAR-T8901-50mg50mg£619.00
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TAR-T8901-100mg100mg£852.00
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Further Information

Bioactivity:
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
CAS:
423145-35-1
Formula:
C21H19ClN2O4
Molecular Weight:
398.84
Pathway:
Metabolism; Cytoskeletal Signaling; GPCR/G Protein; Apoptosis; Endocrinology/Hormones
Purity:
0.9801
SMILES:
CCCC(=O)NC(c1ccc2OCOc2c1)c1cc(Cl)c2cccnc2c1O
Target:
Apoptosis; GPR; HSP

References

Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.