TargetMol

Sepimostat

Product Code:
 
TAR-T8920
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8920-1mg1mg£148.00
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TAR-T8920-5mg5mg£269.00
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TAR-T8920-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T8920-10mg10mg£402.00
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TAR-T8920-25mg25mg£626.00
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TAR-T8920-50mg50mg£862.00
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TAR-T8920-100mg100mg£1,139.00
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Further Information

Bioactivity:
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
CAS:
103926-64-3
Formula:
C21H19N5O2
Molecular Weight:
373.416
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.993
SMILES:
NC(=N)c1ccc2cc(OC(=O)c3ccc(NC4=NCCN4)cc3)ccc2c1
Target:
iGluR

References

Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.