TargetMol

TTA-A2

Product Code:
 
TAR-T8944
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8944-1mg1mg£189.00
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TAR-T8944-5mg5mg£322.00
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TAR-T8944-1mL1 mL * 10 mM (in DMSO)£348.00
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TAR-T8944-10mg10mg£462.00
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TAR-T8944-25mg25mg£701.00
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TAR-T8944-50mg50mg£970.00
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Quantity:
TAR-T8944-100mg100mg£1,259.00
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Further Information

Bioactivity:
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.
CAS:
953778-63-7
Formula:
C20H21F3N2O2
Molecular Weight:
378.395
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.999
SMILES:
C[C@@H](NC(=O)Cc1ccc(cc1)C1CC1)c1ccc(OCC(F)(F)F)cn1
Target:
Calcium Channel

References

Thomas S Reger, et al.Pyridyl amides as potent inhibitors of T-type Richard L Kraus, et al.In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther. 2010 Nov;335(2):409-17.