TargetMol

MONNA

Product Code:
 
TAR-T8960
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8960-1mg1mg£97.00
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TAR-T8960-5mg5mg£142.00
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TAR-T8960-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T8960-10mg10mg£173.00
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TAR-T8960-25mg25mg£303.00
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TAR-T8960-50mg50mg£436.00
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TAR-T8960-100mg100mg£598.00
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Further Information

Bioactivity:
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
CAS:
1572936-83-4
Formula:
C18H14N2O5
Molecular Weight:
338.319
Pathway:
Membrane transporter/Ion channel
Purity:
0.9947
SMILES:
COc1cc(Nc2ccc(cc2C(O)=O)[N+]([O-])=O)cc2ccccc12
Target:
Chloride channel

References

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension[J]. British Journal of Pharmacology, 2019, 176(11). Oh S J , Hwang S J , Jung J , et al. MONNA, a Potent and Selective Blocker for Transmembrane Protein with Unknown Function 16/Anoctamin-1[J]. Molecular Pharmacology, 2013, 84(5):726-735.