TargetMol

API-1

Product Code:
 
TAR-T8969
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8969-1mg1mg£175.00
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TAR-T8969-5mg5mg£283.00
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TAR-T8969-1mL1 mL * 10 mM (in DMSO)£309.00
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TAR-T8969-10mg10mg£422.00
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TAR-T8969-25mg25mg£651.00
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TAR-T8969-50mg50mg£863.00
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Quantity:
TAR-T8969-100mg100mg£1,179.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
CAS:
36707-00-3
Formula:
C13H15N5O6
Molecular Weight:
337.29
Pathway:
PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.9907
SMILES:
C1=C(C(=O)C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N
Target:
Akt

References

Ren H , Koo J , Guan B , et al. The E3 ubiquitin ligases ?-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis[J]. Molecular Cancer, 2013, 12(1):146-146.