TargetMol

AES-350

Product Code:
 
TAR-T9041
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9041-1mg1mg£173.00
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TAR-T9041-5mg5mg£326.00
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TAR-T9041-10mg10mg£495.00
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TAR-T9041-25mg25mg£772.00
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TAR-T9041-50mg50mg£1,018.00
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TAR-T9041-100mg100mg£1,372.00
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TAR-T9041-500mg500mg£2,665.00
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Further Information

Bioactivity:
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
CAS:
847249-57-4
Formula:
C18H20N2O3
Molecular Weight:
312.369
Pathway:
Chromatin/Epigenetic; Apoptosis; DNA Damage/DNA Repair
Purity:
0.992
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO
Target:
Apoptosis; HDAC

References

Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.