TargetMol

BRD0639

Product Code:
 
TAR-T9329
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9329-1mg1mg£136.00
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TAR-T9329-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T9329-5mg5mg£226.00
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TAR-T9329-10mg10mg£298.00
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TAR-T9329-25mg25mg£454.00
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TAR-T9329-50mg50mg£621.00
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Quantity:
TAR-T9329-100mg100mg£870.00
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Further Information

Bioactivity:
BRD0639 is a potent PRMT5 inhibitor. BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation. BRD0639 is a first-in-class PBM-competitive inhibitor that can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions.
CAS:
T9329
Formula:
C21H22ClN5O4S
Molecular Weight:
475.95
Pathway:
Chromatin/Epigenetic
Purity:
0.9946
SMILES:
C[C@@H](C(NC1=CC=C(C(S(=O)(NCCC2=NC=CC=C2)=O)=C1)C)=O)N3C(C=C(C=N3)Cl)=O
Target:
Histone Methyltransferase

References

McKinney DC, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021 Aug 12;64(15):11148-11168.