TargetMol

ASK1-IN-2

Product Code:
 
TAR-T9377
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9377-1mg1mg£140.00
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TAR-T9377-5mg5mg£242.00
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TAR-T9377-1mL1 mL * 10 mM (in DMSO)£259.00
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TAR-T9377-10mg10mg£346.00
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TAR-T9377-25mg25mg£539.00
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TAR-T9377-50mg50mg£741.00
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TAR-T9377-100mg100mg£994.00
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TAR-T9377-500mg500mg£1,910.00
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Further Information

Bioactivity:
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1].
CAS:
2541792-70-3
Formula:
C19H17FN6O
Molecular Weight:
364.38
Pathway:
MAPK; Apoptosis
Purity:
0.9936
SMILES:
CC(C)n1c(-c2cccc(NC(c3cc(ccc(F)c4)c4[nH]3)=O)n2)nnc1
Target:
Apoptosis; ASK; MAPK

References

Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.