TargetMol

CYM50358

Product Code:
 
TAR-T9464
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9464-1mg1mg£111.00
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TAR-T9464-5mg5mg£168.00
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TAR-T9464-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T9464-10mg10mg£230.00
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TAR-T9464-25mg25mg£436.00
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TAR-T9464-50mg50mg£610.00
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Quantity:
TAR-T9464-100mg100mg£838.00
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Further Information

Bioactivity:
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.
CAS:
1314212-39-9
Formula:
C20H18Cl2N2O2
Molecular Weight:
389.28
Pathway:
GPCR/G Protein
Purity:
0.9976
SMILES:
Cc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
Target:
LPL Receptor

References

Guerrero M,et,al.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor.Thromb Res. 2017 Aug;156:91-100.