TargetMol

BAY-8400

Product Code:
 
TAR-T9498
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T9498-1mg1mg£214.00
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Quantity:
TAR-T9498-5mg5mg£431.00
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Quantity:
TAR-T9498-10mg10mg£600.00
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TAR-T9498-25mg25mg£863.00
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Quantity:
TAR-T9498-50mg50mg£1,203.00
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Quantity:
TAR-T9498-100mg100mg£1,581.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BAY-8400 is an orally active, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of 81 nM.
CAS:
T9498
Formula:
C21H17F2N5O
Molecular Weight:
393.39
Pathway:
DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
Purity:
0.9925
SMILES:
FC(F)C1=CN=CC(C2=CC=C(N=CC3=NN=C(C4=CCCOCC4)N35)C5=C2)=C1
Target:
DNA-PK

References

Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762.