TargetMol

Icenticaftor

Product Code:
 
TAR-T9499
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T9499-1mg1mg£370.00
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Quantity:
TAR-T9499-5mg5mg£703.00
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TAR-T9499-10mg10mg£938.00
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TAR-T9499-25mg25mg£1,380.00
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Quantity:
TAR-T9499-50mg50mg£1,821.00
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Quantity:
TAR-T9499-100mg100mg£2,456.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Icenticaftor is an orally active potentiator of?CFTR channel.
CAS:
1334546-77-8
Formula:
C12H13F6N3O3
Molecular Weight:
361.244
Pathway:
Membrane transporter/Ion channel
Purity:
0.9839
SMILES:
COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F
Target:
CFTR

References

Darren Le Grand, et al. Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jun 10;64(11):7241-7260. Steven M Rowe, et al. Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial. Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409.