TargetMol

ARN19702

Product Code:
 
TAR-T9528
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9528-1mg1mg£140.00
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TAR-T9528-1mL1 mL * 10 mM (in DMSO)£180.00
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TAR-T9528-5mg5mg£230.00
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TAR-T9528-10mg10mg£308.00
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TAR-T9528-25mg25mg£470.00
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TAR-T9528-50mg50mg£664.00
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TAR-T9528-100mg100mg£863.00
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TAR-T9528-200mg200mg£1,203.00
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TAR-T9528-500mg500mg£1,661.00
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Further Information

Bioactivity:
ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects[1][2].
CAS:
1971937-18-4
Formula:
C21H22FN3O3S2
Molecular Weight:
447.54
Purity:
1
SMILES:
CCS(=O)(=O)c1ccccc1C(=O)N1CCN(C[C@@H]1C)c1nc2ccc(F)cc2s1

References

Marco Migliore Dr, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76.