TargetMol

KL-11743

Product Code:
 
TAR-T9558
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T9558-1mg1mg£163.00
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TAR-T9558-5mg5mg£269.00
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TAR-T9558-1mL1 mL * 10 mM (in DMSO)£298.00
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TAR-T9558-10mg10mg£389.00
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TAR-T9558-25mg25mg£603.00
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TAR-T9558-50mg50mg£830.00
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TAR-T9558-100mg100mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
CAS:
1369452-53-8
Formula:
C30H30N6O3
Molecular Weight:
522.609
Pathway:
Metabolism
Purity:
0.9812
SMILES:
CCOc1ccc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2c1)-c1cccc(OCC(=O)NC(C)C)c1
Target:
transporter

References

Olszewski K, et al. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2021 Oct 22:S2451-9456(21)00441-4.