TargetMol

Tepotinib hydrochloride(1 : x)

Product Code:
 
TAR-T9601
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9601-1mg1mg£189.00
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TAR-T9601-5mg5mg£340.00
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TAR-T9601-1mL1 mL * 10 mM (in DMSO)£410.00
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TAR-T9601-10mg10mg£470.00
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TAR-T9601-25mg25mg£707.00
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TAR-T9601-50mg50mg£978.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
CAS:
1103508-80-0
Formula:
C29H29ClN6O2
Molecular Weight:
529.04
Pathway:
Neuroscience; Tyrosine Kinase/Adaptors; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
0
Target:
c-Met/HGFR; P-gp; ABC

References

Vagiannis D, et al. Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo. Int J Mol Sci. 2021 Nov 3;22(21):11936. Wu ZX, et al. Tepotinib hydrochloride for the treatment of non-small cell lung cancer. Drugs Today (Barc). 2021 Apr;57(4):265-275.