TargetMol

UC2288

Product Code:
 
TAR-T9698
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9698-1mg1mg£103.00
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TAR-T9698-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T9698-5mg5mg£148.00
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TAR-T9698-10mg10mg£189.00
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TAR-T9698-25mg25mg£292.00
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TAR-T9698-50mg50mg£402.00
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TAR-T9698-100mg100mg£483.00
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TAR-T9698-200mg200mg£584.00
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TAR-T9698-500mg500mg£816.00
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Further Information

Bioactivity:
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.
CAS:
1394011-91-6
Formula:
C20H18ClF6N3O2
Molecular Weight:
481.82
Pathway:
Apoptosis
Purity:
0.98
SMILES:
FC(F)(F)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc1
Target:
Mdm2; p53

References

Jun Hyung Im, et al. p21 inhibitor UC2288 ameliorates MPTP induced Parkinson?s disease progression through inhibition of oxidative stress and neuroinammation. Translational Medicine.Neurobiology of Disease Romi Gupta, et al. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3062-71. Hiromi I Wettersten, et al. A Novel p21 Attenuator Which Is Structurally Related to Sorafenib. Cancer Biol Ther. 2013 Mar;14(3):278-85.