TargetMol

GSK778

Product Code:
 
TAR-T9703
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9703-1mg1mg£204.00
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TAR-T9703-5mg5mg£337.00
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TAR-T9703-1mL1 mL * 10 mM (in DMSO)£371.00
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TAR-T9703-10mg10mg£497.00
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TAR-T9703-25mg25mg£870.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a cell cycle arrest and apoptosis.
CAS:
2451862-42-1
Formula:
C30H33N5O3
Molecular Weight:
511.61
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
C[C@H](c1ccccc1)n1c2c(cc(c(-c3c(C)onc3C)c3)OC[C@@H]4CNCC4)c3ncc2nc1COC
Target:
Epigenetic Reader Domain

References

Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394.