TargetMol

GSK778 hydrochloride

Product Code:
 
TAR-T9703L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9703L-1mg1mg£227.00
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TAR-T9703L-5mg5mg£422.00
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TAR-T9703L-1mL1 mL * 10 mM (in DMSO)£521.00
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TAR-T9703L-10mg10mg£589.00
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TAR-T9703L-25mg25mg£863.00
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TAR-T9703L-50mg50mg£1,179.00
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Quantity:
TAR-T9703L-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 hydrochloride hydrochloride phenocopies the effects of pan-BET inhibitors in cancer models[1].
CAS:
0
Formula:
C30H34ClN5O3
Molecular Weight:
548.08
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
C[C@@H](N1C(COC)=NC2=C1C3=CC(OC[C@@H]4CNCC4)=C(C5=C(C)ON=C5C)C=C3N=C2)C6=CC=CC=C6.[H]Cl
Target:
Epigenetic Reader Domain

References

Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394.