TargetMol

INE963

Product Code:
 
TAR-T9741
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9741-1mg1mg£116.00
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TAR-T9741-5mg5mg£181.00
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TAR-T9741-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T9741-10mg10mg£242.00
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TAR-T9741-25mg25mg£420.00
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TAR-T9741-50mg50mg£587.00
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TAR-T9741-100mg100mg£805.00
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Further Information

Bioactivity:
INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50?s ranging from 0.01 to 7.0 nM
CAS:
2640567-43-5
Formula:
C19H26N6O2S
Molecular Weight:
402.51
Purity:
0.98
SMILES:
CC(C)c(cc1)nc(OC)c1-c1cnc2sc(N(CC3)CCC3(CN)O)nn12

References

Taft BR, et, al. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. J Med Chem. 2022 Mar 10;65(5):3798-3813.