TargetMol

MKC-1

Product Code:
 
TAR-T9831
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9831-1mg1mg£140.00
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TAR-T9831-5mg5mg£242.00
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TAR-T9831-1mL1 mL * 10 mM (in DMSO)£259.00
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TAR-T9831-10mg10mg£322.00
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TAR-T9831-25mg25mg£506.00
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TAR-T9831-50mg50mg£699.00
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TAR-T9831-100mg100mg£946.00
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TAR-T9831-500mg500mg£1,830.00
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This product comes from: United States.
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Further Information

Bioactivity:
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in
CAS:
125313-92-0
Formula:
C22H16N4O4
Molecular Weight:
400.394
Pathway:
Apoptosis; PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)[N+]([O-])=O)c2ccccc12
Target:
Apoptosis; Akt; Microtubule Associated; mTOR

References

Jason E Faris,et al. A phase 2 study of oral MKC-1, an inhibitor of importin-?, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.Invest New Drugs. 2012 Aug;30(4):1614-20.