TargetMol

3'-Demethylnobiletin

Product Code:
 
TAR-TN1244
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1244-1mg1mg£138.00
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TAR-TN1244-5mg5mg£228.00
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TAR-TN1244-1mL1 mL * 10 mM (in DMSO)£247.00
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TAR-TN1244-10mg10mg£307.00
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This product comes from: United States.
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Further Information

Bioactivity:
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death.
CAS:
112448-39-2
Formula:
C20H20O8
Molecular Weight:
388.372
Pathway:
Metabolism; Cytoskeletal Signaling; DNA Damage/DNA Repair; Cell Cycle/Checkpoint; NF-κb
Purity:
0.9987
SMILES:
COc1ccc(cc1O)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1
Target:
LDL; NF-κB; Integrin; Lipoxygenase; DNA/RNA Synthesis

References

Eguchi A, et al. Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. Biofactors. 2007;31(2):107-16.