TargetMol

Ayanin

Product Code:
 
TAR-TN1416
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1416-1mg1mg£306.00
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TAR-TN1416-5mg5mg£570.00
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TAR-TN1416-10mg10mg£777.00
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TAR-TN1416-25mg25mg£1,099.00
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TAR-TN1416-50mg50mg£1,476.00
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Quantity:
TAR-TN1416-100mg100mg£1,974.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.
CAS:
572-32-7
Formula:
C18H16O7
Molecular Weight:
344.319
Pathway:
Metabolism; Chromatin/Epigenetic; Immunology/Inflammation; DNA Damage/DNA Repair
Purity:
0.989
SMILES:
COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O
Target:
IL Receptor; P45; PARP; PDE

References

Fei-Peng Lee, et al. Ayanin, a Non-Selective Phosphodiesterase 1-4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness Without Affecting xylazine/ketamine-induced Anesthesia. Eur J Pharmacol. 2010 Jun 10;635(1-3):198-203. Marrero MT, et al. Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells. Biochem Biophys Res Commun. 2012 Nov 9;428(1):116-20.