TargetMol

Isosilybin A

Product Code:
 
TAR-TN1804
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN1804-25mg25mgEnquire
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TAR-TN1804-50mg50mgEnquire
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TAR-TN1804-1mg1mg£135.00
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TAR-TN1804-5mg5mg£230.00
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TAR-TN1804-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-TN1804-10mg10mg£309.00
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Further Information

Bioactivity:
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
CAS:
142796-21-2
Formula:
C25H22O10
Molecular Weight:
482.441
Pathway:
Membrane transporter/Ion channel; Apoptosis; Proteases/Proteasome; Metabolism; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Target:
Apoptosis; Tyrosinase; PPAR; ABC

References

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.