TargetMol

Yangambin

Product Code:
 
TAR-TN2322
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2322-1mg1mg£301.00
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TAR-TN2322-5mg5mg£626.00
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TAR-TN2322-1mL1 mL * 10 mM (in DMSO)£758.00
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TAR-TN2322-10mg10mg£862.00
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TAR-TN2322-25mg25mg£1,267.00
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TAR-TN2322-50mg50mg£1,645.00
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Further Information

Bioactivity:
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin has central nervous system activity, it presents a depressant activity in the open field, forced swimming and pentobarbital sleeping time tests.
CAS:
13060-14-5
Formula:
C24H30O8
Molecular Weight:
446.496
Pathway:
Membrane transporter/Ion channel; GPCR/G Protein; Metabolism
Purity:
0.9802
SMILES:
COc1cc(cc(OC)c1OC)[C@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1cc(OC)c(OC)c(OC)c1
Target:
Calcium Channel; PAFR

References

Ara?jo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.