TargetMol

2'-Hydroxydaidzein

Product Code:
 
TAR-TN2766
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN2766-1mg1mg£189.00
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Further Information

Bioactivity:
2'-Hydroxygenistein is an isoflavonoid phytoalexin, it suppresses chemical mediators in inflammatory cells, may have value in treatment and prevention of central and peripheral inflammatory diseases associated with excess production of chemical mediators. 2'-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) with IC(50) values of 2.8+/-0.1 and 5.9+/-1.4 microM, respectively.
CAS:
7678-85-5
Formula:
C15H10O5
Molecular Weight:
270.24
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
Oc1ccc(c(O)c1)-c1coc2cc(O)ccc2c1=O
Target:
NADPH-oxidase

References

Fischer D, et al. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. Arch Biochem Biophys. 1990 ; 276(2):390-395. Ko HH, et al. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. Bioorg. Med. Chem. Lett. 2004 ; 14(22):1011-1014.