TargetMol

Nauclefine

Product Code:
 
TAR-TN6120
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN6120-25mg25mgEnquire
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TAR-TN6120-50mg50mgEnquire
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TAR-TN6120-1mg1mg£230.00
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TAR-TN6120-2mg2mg£309.00
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TAR-TN6120-5mg5mg£430.00
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TAR-TN6120-10mg10mg£600.00
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Further Information

Bioactivity:
Nauclefine is a plant indole alkaloid natural product and induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not inhibit the PDE3A's phosphodiesterase activity.
CAS:
57103-51-2
Formula:
C18H13N3O
Molecular Weight:
287.32
Pathway:
Metabolism
Purity:
0.9992
SMILES:
O=C1C=2C=NC=CC2C=C3C=4NC=5C=CC=CC5C4CCN13
Target:
PDE

References

Ai Y, et al. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. Nat Commun. 2020 Jun 26;11(1):3236.