TargetMol

ALX 40-4C acetate

Product Code:
 
TAR-TP1364L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-TP1364L-1mg1mg£248.00
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TAR-TP1364L-5mg5mg£687.00
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TAR-TP1364L-10mg10mg£992.00
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TAR-TP1364L-25mg25mg£1,675.00
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This product comes from: United States.
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Further Information

Bioactivity:
ALX 40-4C acetate is a CXCR4 inhibitor of the chemokine receptor (Ki = 1 μM) and suppresses the replication of X4 strains of HIV-1. ALX 40-4C acetate is an antagonist of the APJ receptor (IC50 = 2.9 μM).
CAS:
TP1364L
Formula:
C58H117N37O12
Molecular Weight:
1524.79
Pathway:
Autophagy; Immunology/Inflammation; GPCR/G Protein
Purity:
0.98
SMILES:
CC(O)=O.NC([C@H](NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O
Target:
Apelin receptor; CXCR

References

Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. Armand-Ug?n M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86.