TargetMol

DX600 TFA

Product Code:
 
TAR-TP1622
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1622-1mg1mg£201.00
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Quantity:
TAR-TP1622-2mg2mg£266.00
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TAR-TP1622-5mg5mg£402.00
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TAR-TP1622-10mg10mg£567.00
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TAR-TP1622-25mg25mg£862.00
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TAR-TP1622-50mg50mg£1,139.00
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Quantity:
TAR-TP1622-100mg100mg£1,508.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
DX600 TFA is a specific inhibitor of ACE2 and does not cross-react with ACE.
CAS:
TP1622
Formula:
C123H169F3N32O39S2
Molecular Weight:
2841.01
Pathway:
Endocrinology/Hormones
Purity:
0.9954
SMILES:
OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(N)=O
Target:
RAAS

References

Zheng Z, Bo W, Lv X, et al. Protective Effect of SIRT6 on Cholesterol Crystal-induced Endothelial Dysfunction via Regulating ACE2 Expression. Experimental Cell Research. 2021 May 1;402(1):112526. doi: 10.1016/j.yexcr.2021.112526. Epub 2021 Feb 22. Zheng Z, Bo W, Lv X, et al. Protective Effect of SIRT6 on Cholesterol Crystal-induced Endothelial Dysfunction via Regulating ACE2 Expression[J]. Experimental Cell Research. 2021: 112526. Liao K, et al. Development of an enzymatic assay for the detection of neutralizing antibodies against therapeutic angiotensin-converting enzyme 2 (ACE2).J Immunol Methods.?2013 Mar 29;389(1-2):52-60.