TargetMol

Pep 2-8 ammonium salt(1541011-97-5 free base)

Product Code:
 
TAR-TP1881L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1881L1-1mg1mg£181.00
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Quantity:
TAR-TP1881L1-5mg5mg£319.00
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TAR-TP1881L1-10mg10mg£442.00
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TAR-TP1881L1-25mg25mg£683.00
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TAR-TP1881L1-50mg50mg£930.00
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Quantity:
TAR-TP1881L1-100mg100mg£1,219.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
CAS:
TP1881L1
Formula:
C83H113N17O24
Molecular Weight:
1732.91
Purity:
0.9987
SMILES:
C[C@@H](O)[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CC1=CNC2=CC=CC=C21)=O)CC(O)=O)=O)CC(C)C)=O)CC3=CC=C(O)C=C3)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC4=CNC5=CC=CC=C54)=O)CO)=O)[C@H](O)C)=O)CC6=CC=CC=C6)=O)C(C)C)=O.N

References

Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID: